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Monolayers of hiPSC-derived endothelial cells from Alzheimer's patients with PSEN1 and PSEN2 mutations, differentiated with a chemically defined medium, possessed a low TEER, reduced expression of claudin-5, occludin, and ZO1 protein, and impaired glucose transport (Raut et al., 2021)

ASCT2 is overexpressed on the surface of various tumor cells, such as gastric cancer (Ma et al., 2021), colon cancer (Ma et al., 2018), pancreatic cancer (Wang et al., 2022), and TNBC (Van Geldermalsen et al., 2016)

References: Patel et al

For many of us, getting enough B12 to truly thrive can be a challenge, which is where treatments like B12 injections come in